Cinnamon and Alzheimer's

Plants have a long history as a rich source of new compounds for drug discovery. Cinnamon is widely used by humans, both as a spice and as a traditional medicine. It is, perhaps, one of the oldest herbal medicines, having been mentioned in the Bible and in Chinese texts as long as 4,000 years ago.

Previous studies have already demonstrated the potential for herbal extracts to interact with beta-amyloid, and perhaps slow down or even prevent AD. As we move towards earlier identification of Alzheimer’s disease pathology in minimally symptomatic individuals, such therapies will undoubtedly become areas of intense research. Examples for extensively studied naturally occurring compounds are the (-)-epigallocatechin-3-gallate (EGCG) from green tea and Curcumin, which is derived from the natural turmeric.

Now, a research team headed by Michael Ovadia from Tel Aviv University, has isolated one of the ingredients in cinnamon, CEppt, and used it in a series of tests conducted on two-month-old lab mice that were raised with five aggressive strains of Alzheimer’s-inducing genes. The experiment’s results, recently published in the PLoS ONE scientific journal, were impressive. Laboratory rodents, genetically altered to develop dementia, received either the cinnamon extract or an inert treatment for four months. The extract improved the rats’ performance on learning and memory tasks. It also reduced the amount of plaque formed in the brain. The animals were fed drinking water containing a CEppt solution over four months, and researchers found that the disease’s development was delayed, with additional trials showing that existing amyloids had been dissolved. The results show the ability of CEppt to inhibit the progress of beta-amyloid aggregation. CEppt is actually comprised of several molecules, and it remains to be found which molecule is exerting this effect.

Supplements such as Curcumin, EGCG, DHA and CEppt will likely be evaluated in clinical trials in patients who have minimal symptoms, but are on the path towards developing AD. That is, patients with amyloid building up in the brain, but not yet showing symptoms as assessed by Amyloid scans (for example. From studies such as ADNI, we believe that there is a 15 year window during which amyloid is building up in the brain, while there are minimal symptoms, such as memory loss present. This window may be the best time to initiate anti-amyloid therapy.)

Anat Frydman-Marom, et al, Orally Administrated Cinnamon Extract Reduces ß-Amyloid Oligomerization and Corrects Cognitive Impairment in Alzheimer’s Disease Animal Models; PLoS One Jan. 28, 2011

Michael S. Rafii, M.D., Ph.D.

Director, Memory Disorders Clinic
Associate Medical Core Director, Alzheimer’s Disease Cooperative Study
University of California San Diego

This post originally appeared in Alzheimer’s Insights, an ADCS Blog.

Source: http://blog.alz.org/cinnamon-and-ad

The End of Alzhemier's Starts With Me

We will be wearing purple on September 21 to help raise awareness during World Alzheimer's Month. You CAN make a difference

National Assisted Living Week September 11-17, 2011: Live Life

National Assisted Living Week begins on, Sunday, September 11, 2011.  Many assisted living residents are the people who made significant contributions to our community; teachers, business people, civic leaders, public officials, parents, and now grandparents. 

Assisted living has emerged as a popular senior living option for those elderly people who need some assistance with activities of daily living, but are able to live and function for the most part on their own.  A typical assisted living home offers 24-hour monitoring of its residents, common cares, including meals, housekeeping, laundry services, bathing, dressing, ambulating, and medication assistance while respecting their dignity and enhancing their quality of life.  There is specialized Alzheimer’s care units designed with safety features for those suffering from Alzheimer’s or other forms of dementia.

How Can I Tell When My Loved One Needs More Help Than I Can Provide?

The following warning signs may indicate that it’s time for a talk about assisted living: 

• Your loved one needs more help than family and friends are able to provide.
• They feel lonely and isolated in their home.
• Family members are worried for their safety.
• The refrigerator is empty or filled with spoiled food.
• You notice frequent bruises on your loved one.
• Your loved one wears the same clothes over and over again.
• The house and yard isn’t as clean as it used to be.
• Your loved one become increasingly forgetful.
• Your loved one seems depressed.
• You notice strange or inappropriate behavior. 

Choosing an Assisted Living Home

The most important factor when choosing an assisted living home is that it feels friendly, safe, and comfortable for your loved one and family.  Things to consider when choosing an assisted living home; does the staff speak with you and appear genuinely interested in you, do they interact warmly with residents, do residents appear happy, do they appear to be enjoying and interacting with others, does it feel homey to you, is there an activity program, are there home cooked meals that are appealing, nutritious, and appetizing, do they handle health problems, is the facility in compliance with state and local licensing requirements. 

In evaluating assisted living, cost most likely will be a consideration, so take the time to check if you’re loved ones long term insurance, health insurance, or governmental programs will cover any of the costs of assisted living. Don’t assume that expensive means better; make sure you understand how the facility bills or do additional services require additional costs, and understand their rate increases.  Your goal should be to find the right facility where you feel most at home that is best for your loved one and family. 

Lori Schuler is the Marketing and Activity Director for Central Wisconsin Senior Living.